In the production process of sterile drugs, especially for non-terminal sterilized products, sterilization filtration and aseptic production processes are mainly relied on to achieve sterility control requirements. With the widespread application of sterilizing filtration technology in the pharmaceutical industry, the risks of sterilizing filtration have also attracted major attention in the industry. Let’s learn more about it with the 0.22um filter membrane manufacturer.
As early as the 1960s, membrane filters appeared on the market. At that time, membrane filters containing 0.45 micron pore sizes were considered “sterile grade” liquid filters and were successfully used for sterilizing filtration of injections. Because the bubble point value of this membrane is approximately twice that of traditional 0.45 micron “sterilizing grade” membranes. Millipore divided 0.45 by 2 and named it 0.22 micron membrane. This naming is based on people’s common understanding: the bubble point value is inversely proportional to the filter membrane pore size.
Filtration sterilization refers to a method that uses the principle that small bacteria cannot pass through dense porous filter materials to remove microorganisms in gases or liquids. It is often used for sterilization of gases, thermally unstable pharmaceutical solutions or raw materials.
The sterilizing filter uses a microporous filter membrane with uniform pore size distribution as the filter material. Microporous filter membranes are divided into two types: hydrophilic and hydrophobic. The material of the filter membrane depends on the nature of the filtered items and the purpose of filtration.
The sterilizing filter membrane used in pharmaceutical production is the 0.22um filter membrane. The pore size of a filter is defined by the filter’s retention of microorganisms, rather than the distribution coefficient of the average pore size. Therefore, the filter used for final sterilization needs to choose a sterilizing grade filter with retention test proof.
The currently independently developed 0.22um filter membrane series is the core material of the sterilization filter, which has both hydrophobic and hydrophilic properties. categories. 0.22um filter membrane is widely used in medicine, food, beverage, beer, chemical and other industries, such as the filtration of sterile raw materials and liquid sterilization in the pharmaceutical industry, and the filtration of liquor, beverages, etc. in the food industry. Filtration of wine, fruit wine, etc., filtration of organic solvents, various alcohols, chemical reagents, etc. in the chemical industry. Interested parties are welcome to enter the store for consultation.
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